The Mechanism of Chemoprotection by 1-Cyano-2-Hydroxy-3-Butene, a Natural Component of Cruciferous Vegetables
Staack, Richard Frank
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https://hdl.handle.net/2142/84976
Description
Title
The Mechanism of Chemoprotection by 1-Cyano-2-Hydroxy-3-Butene, a Natural Component of Cruciferous Vegetables
Author(s)
Staack, Richard Frank
Issue Date
1997
Doctoral Committee Chair(s)
Jeffery, Elizabeth H.
Department of Study
Nutritional Sciences
Discipline
Nutritional Sciences
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Health Sciences, Oncology
Language
eng
Abstract
In a final study, CHB was found to mediate a monofunctional DNA-directed increase in GST subunit Ya$\sb2,$ Yc$\sb2$ and QR mRNA levels, without a concomitant increase in mRNA levels of CYP 1A. This suggests that, in the previous study, the protection afforded against aflatoxin-induced carcinogenesis was through a monofunctional increase in phase II enzymes, particularly, the GST subunit Yc$\sb2.$ (Abstract shortened by UMI.).
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