Toward an Understanding of Interindividual Variation in Hydrogenotrophic Microbes in the Human Colon

Nava-Morales, Gerardo Manuel

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Description

Title

Toward an Understanding of Interindividual Variation in Hydrogenotrophic Microbes in the Human Colon

Author(s)

Nava-Morales, Gerardo Manuel

Issue Date

2009

Doctoral Committee Chair(s)

Donovan, Sharon M.

Department of Study

Nutritional Sciences

Discipline

Nutritional Sciences

Degree Granting Institution

University of Illinois at Urbana-Champaign

Degree Name

Ph.D.

Degree Level

Dissertation

Keyword(s)

Biology, Microbiology

Language

eng

Abstract

Chapter 4 describes the diversity of colonic SRB and methanogens in native African (NA), African American (AA) and Caucasian American (CA) healthy subjects. In this study, stool samples from NA, who were consuming a diet low in animal protein, versus AA and CA, with both cohorts consuming a typical Western diet, were used to examine the diversity of SRB and methanogenic microbes using PCR-based methods. Inferential and multivariate statistical analyses revealed that SRB populations in NA are more homogenous than in AA and that SRB communities in NA are distinguishable from those in AA and CA. Also, it was revealed that the African groups, NA and AA, harbor different Archaea populations than CA and that the microbial communities in NA and AA are distinguishable from those in CA. This observation is consistent with the hypothesis that interactions among ethnic background, diet and microbial mechanisms of H2 disposal may influence susceptibility to sporadic colorectal cancer. (Abstract shortened by UMI.).

Graduation Semester

2009

Type of Resource

text

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