Impact of Dietary Carbohydrate and Protein Levels on Carbohydrate Metabolism
Lasker, Denise Ann
This item is only available for download by members of the University of Illinois community. Students, faculty, and staff at the U of I may log in with your NetID and password to view the item. If you are trying to access an Illinois-restricted dissertation or thesis, you can request a copy through your library's Inter-Library Loan office or purchase a copy directly from ProQuest.
Permalink
https://hdl.handle.net/2142/84967
Description
Title
Impact of Dietary Carbohydrate and Protein Levels on Carbohydrate Metabolism
Author(s)
Lasker, Denise Ann
Issue Date
2009
Doctoral Committee Chair(s)
Evans, Ellen M.
Department of Study
Nutritional Sciences
Discipline
Nutritional Sciences
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Biology, Physiology
Language
eng
Abstract
The third objective evaluated differential tissue responses in gene expression and metabolic signaling in liver, muscle, and adipose tissue associated with diets containing 58%, 40%, or 25% of energy as CARB. These diets represent high (HC), moderate (MC), and low (LC) CARB amounts within the acceptable macronutrient distribution range for the DRI. This study was designed to identify the range of metabolic adaptations required to maintain glucose homeostasis across the recommended dietary range of CARB. While plasma glucose was maintained within normal range, as dietary CARB increased in the diet, there was a progression of saturation of hepatic glucose regulations including increased post-prandial glycogen, decreased GNG capacity (decreased expression of PEPCK) with increased lipogenic activity (increased FAS expression) in addition to the corresponding SREBP1c expression in liver. This increase in dietary CARB then exceeded skeletal muscle utilization of glucose, becoming reliant on adipose uptake of glucose: increased glucose uptake into muscle in addition to patterns observed in insulin signaling elements and FAS expression in adipose tissue. Though optimal macronutrient content remains unknown, increases in physiologic ranges of CARB in the diet produce huge shifts in metabolism while maintaining glucose homeostasis. (Abstract shortened by UMI.).
Use this login method if you
don't
have an
@illinois.edu
email address.
(Oops, I do have one)
IDEALS migrated to a new platform on June 23, 2022. If you created
your account prior to this date, you will have to reset your password
using the forgot-password link below.
