Beneficial Effect of the Flavonoid Luteolin on Neuroinflammation
Jang, Saebyeol
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https://hdl.handle.net/2142/84966
Description
Title
Beneficial Effect of the Flavonoid Luteolin on Neuroinflammation
Author(s)
Jang, Saebyeol
Issue Date
2009
Doctoral Committee Chair(s)
Kelley, Keith W.
Department of Study
Nutritional Sciences
Discipline
Nutritional Sciences
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Health Sciences, Immunology
Language
eng
Abstract
Finally, given these potent anti-inflammatory properties of luteolin, as well as the inverse relationship between flavonoid intake and cognitive decline in older persons and aged animals reported by others, we explored whether dietary supplementation of luteolin can ameliorate age-related deficits in spatial working memory and reduce inflammatory molecules in aged brain. Adult and aged mice were provided control or luteolin supplemented diet for four weeks. Dietary supplementation of luteolin attenuated the age-related spatial working memory deficits along with alleviating hippocampal IL-1beta and major histocompatibility complex (MHC) class II mRNA expression in aged mice. Collectively, these studies showed that luteolin might be a promising agent for preventing neuroinflammation and neuronal cell death mediated by activated microglia and consequently, attenuating age-associated cognitive decline.
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