University of Illinois Urbana-Champaign

The Effect of Dietary Genistein on Breast Cancer Treatment and Metastasis

Du, Mengyuan

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Description

Title
The Effect of Dietary Genistein on Breast Cancer Treatment and Metastasis
Author(s)
Du, Mengyuan
Issue Date
2009
Doctoral Committee Chair(s)
  • Cooke, Paul S.
  • Helferich, William G.
Department of Study
Nutritional Sciences
Discipline
Nutritional Sciences
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Health Sciences, Nutrition
Language
eng
Abstract
In the first study, we demonstrated that low dose dietary genistein negated the inhibitory effect of tamoxifen on mammary tumor growth. Although high dose genistein did not show the same effect, high tumor prevalence was observed. In the second study, dietary genistein was shown to promote breast cancer metastasis to lungs in athymic mice. The results from these studies suggest that the consumption of dietary supplements containing genistein may not be safe to breast cancer survivors. In our third study, we evaluated three metastasis models using different injection sites. We have successfully developed animal models that can produce a proper level of distant metastasis. These preclinical animal models will allow us to conduct further research to investigate the impact of soy isoflavones on breast cancer metastasis in the future.
Graduation Semester
2009
Type of Resource
text
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http://hdl.handle.net/2142/84961

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Dissertations and Theses - Nutritional Sciences