Combination of Dietary Tomato and Broccoli Powders Are Effective Growth Inhibitors of Dunning R3327-H Prostate Adenocarcinomas
Adams, Kirstie Anne-Merrea
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https://hdl.handle.net/2142/84950
Description
Title
Combination of Dietary Tomato and Broccoli Powders Are Effective Growth Inhibitors of Dunning R3327-H Prostate Adenocarcinomas
Author(s)
Adams, Kirstie Anne-Merrea
Issue Date
2007
Doctoral Committee Chair(s)
Erdman, John W.
Department of Study
Nutritional Sciences
Discipline
Nutritional Sciences
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Health Sciences, Oncology
Language
eng
Abstract
Tumor growth suppression was associated with reduced proliferation and increased apoptosis, as quantified by Proliferating Cell Nuclear Antigen (PCNA) immunohistochemistry and the ApoptagRTM assay, respectively. Utilizing real time polymerase chain reactions (RT-PCR) and the SYBR Green assay, mRNA was quantified in the liver, prostate, and tumors. Finasteride significantly decreased expression of 5-alpha-reductase-II, Bcl-2, and IL-6 in tumors. IL-6 was reduced in high lycopene and broccoli, P=0.05, and TNF-alpha was lower with low lycopene, P=0.05. Overall, the combination of tomato and broccoli powders was more effective at slowing tumor growth than either tomato powder or broccoli powder alone.
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