Intestinal Development and Gene Expression of Piglets Suckling Sows Transgenic for Human Insulin-Like Growth Factor-I
Hartke, Jessica L.
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https://hdl.handle.net/2142/84948
Description
Title
Intestinal Development and Gene Expression of Piglets Suckling Sows Transgenic for Human Insulin-Like Growth Factor-I
Author(s)
Hartke, Jessica L.
Issue Date
2006
Doctoral Committee Chair(s)
Donovan, Sharon M.
Department of Study
Nutritional Sciences
Discipline
Nutritional Sciences
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Health Sciences, Nutrition
Language
eng
Abstract
We have shown that piglets suckling IGF exhibit structural and functional changes similar to those observed in piglets receiving formula supplemented with IGF-I. The location and timing of the response to IGF-I differs from previous studies. Insulin like growth factor-I appeared to act via the type I IGF receptor at d 21 in the ileum of piglets suckling IGF. Microarray analysis elucidated differentially expressed genes involved in proliferation, as well as genes involved in immune function and metabolism, suggesting new avenues for IGF-I research.
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