The Effects of Soy and Soy Derived Components on the Growth of Estrogen -Dependent Breast Cancer Tumors
Allred, Clinton David
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https://hdl.handle.net/2142/84931
Description
Title
The Effects of Soy and Soy Derived Components on the Growth of Estrogen -Dependent Breast Cancer Tumors
Author(s)
Allred, Clinton David
Issue Date
2002
Doctoral Committee Chair(s)
Helferich, William G.
Department of Study
Nutritional Sciences
Discipline
Nutritional Sciences
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Health Sciences, Oncology
Language
eng
Abstract
The purpose of the studies presented here was to determine if: (1) the chemical form of genistein affects its ability to stimulate the growth of estrogen-dependent breast cancer tumors, (2) the matrix of the food in which the isoflavone is consumed influences its activity in vivo, and (3) genistein would stimulate the growth of chemically induced mammary tumors in rats. The first study was designed to determine if dietary genistin, the glycoside form of genistein, was capable of stimulating the growth of MCF-7 tumors transplanted into athymic mice. Dietary genistin resulted in increased tumor growth rate and cellular proliferation similar to that observed with genistein. The objective of the second study was to evaluate the ability of various soy products containing genistin, but differing in their content of other biologically active components of soy, to affect the growth of MCF-7 tumors. Soy products investigated included whole soy flour, soy molasses, NovasoyRTM, a mixture of isoflavones, and genistin in pure form. Each of the products was fed so that it would provide equivalent amounts of genistin. MCF-7 tumor growth was stimulated in animals consuming soy molasses, NovasoyRTM, the mixture of isoflavones, and genistin alone. Tumors in mice consuming soy flour with an equal concentration of genistin maintained their original size, but did not grow. Collectively these data suggest that the matrix of the food in which genistein is consumed may impact it's activity. The final study was designed to evaluate how genistein would affect growth of chemically-induced mammary tumors in rats. We found that in ovariectomized rats dietary genistein increased the wet weight of tumors compared to control animals.
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