Yeast Mutants That Require the GPI Biosynthetic Gene GPI1 for Growth
Taron, Barbara Westfall
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https://hdl.handle.net/2142/84920
Description
Title
Yeast Mutants That Require the GPI Biosynthetic Gene GPI1 for Growth
Author(s)
Taron, Barbara Westfall
Issue Date
2000
Doctoral Committee Chair(s)
Peter A.B.Orlean
Department of Study
Biochemistry
Discipline
Biochemistry
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Biology, Molecular
Language
eng
Abstract
The isolation of t-s smp3, gaa1, and gpi2 strains using a synthetic lethality screen demonstrates that this is a valid approach to identify genes involved in GPI anchor biosynthesis. This suggests that many of the remaining S.L. mutants are also likely to harbor mutations in GPI and cell wall assembly. Strategies to identify the remaining non- t-s/S.L. mutations include complementation of other conditional growth phenotypes (e.g. CFW hypersensitivity) or the non-sectoring phenotype.
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