University of Illinois Urbana-Champaign

Characterization of the Yeast Gpi3 Protein, the Catalytic Subunit of the First Enzyme Complex in GPI Anchor Biosynthesis

Kostova, Zlatka

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Description

Title
Characterization of the Yeast Gpi3 Protein, the Catalytic Subunit of the First Enzyme Complex in GPI Anchor Biosynthesis
Author(s)
Kostova, Zlatka
Issue Date
1999
Doctoral Committee Chair(s)
Peter A.B.Orlean
Department of Study
Biochemistry
Discipline
Biochemistry
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Biology, Molecular
Language
eng
Abstract
I also undertook to disrupt the S. pombe gpi3 + gene and to carry out comparative studies of the fungal and human Gpi3p homologs. The S. pombe gpi3+ gene was found to be essential for cell viability in this organism. The in vivo complementation studies indicated that the S. pombe, S. cerevisiae, and H. sapiens enzymes, although very similar at the amino acid level, do not complement each other.
Graduation Semester
1999
Type of Resource
text
Permalink
http://hdl.handle.net/2142/84909

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Dissertations and Theses - Biochemistry