University of Illinois Urbana-Champaign

Use of Fluorescence to Study the Membrane Binding Domain of Cytochrome B(5) and the Induction of Membrane Domain Formation in Phospholipid Vesicles by Myelin Basic Protein

Harvey, John Jay

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Description

Title
Use of Fluorescence to Study the Membrane Binding Domain of Cytochrome B(5) and the Induction of Membrane Domain Formation in Phospholipid Vesicles by Myelin Basic Protein
Author(s)
Harvey, John Jay
Issue Date
1997
Doctoral Committee Chair(s)
Glaser, Michael
Department of Study
Biochemistry
Discipline
Biochemistry
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Biology, Molecular
Language
eng
Abstract
The mechanism of membrane domain formation was investigated through analysis of domains induced both by calcium and myelin basic protein in vesicles containing components normally enriched in myelin. In the presence of calcium or myelin basic protein, domains enriched in phosphatidic acid, phosphatidylserine, galactocerebroside, and sulfatide were observed to form. In these domains phosphatidic acid or phosphatidylserine co-localized with galactocerebroside and sulfatide. Sphingomyelin was unable to partition into a domain unless sulfatide was also present.
Graduation Semester
1997
Type of Resource
text
Permalink
http://hdl.handle.net/2142/84877

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