Oxidation of Alkenes by Caldariomyces Fumago Chloroperoxidase
Dexter, Annette Faith
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https://hdl.handle.net/2142/84876
Description
Title
Oxidation of Alkenes by Caldariomyces Fumago Chloroperoxidase
Author(s)
Dexter, Annette Faith
Issue Date
1997
Doctoral Committee Chair(s)
Hager, Lowell P.
Department of Study
Biochemistry
Discipline
Biochemistry
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Chemistry, Biochemistry
Language
eng
Abstract
To elucidate factors involved in the control of CPO heme N-alkylation by terminal alkenes, the epoxidation of a series of monosubstituted and 1,1-disubstituted terminal alkenes by CPO was investigated. Terminal alkenes containing a 2-methyl substituent did not inactivate CPO even when the corresponding monosubstituted alkene inactivated the enzyme. The inverse correlation between the epoxidation enantioselectivity and the tendency to heme N-alkylation suggested that CPO inactivation by terminal alkenes is controlled by steric properties of the alkene and the enzyme active site. (Abstract shortened by UMI.).
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