The Role of T Cell Receptor: Peptide MHC Affinity in T Cell Activation
Chervin, Adam S.
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https://hdl.handle.net/2142/84862
Description
Title
The Role of T Cell Receptor: Peptide MHC Affinity in T Cell Activation
Author(s)
Chervin, Adam S.
Issue Date
2009
Doctoral Committee Chair(s)
Kranz, David M.
Department of Study
Biochemistry
Discipline
Biochemistry
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Chemistry, Biochemistry
Language
eng
Abstract
Engineering of TCRs requires stabilization of the receptor prior to engineering for higher affinity. Chapter 4 details the engineering of a high affinity TCR in its native state, without the need for stabilization, using a T cell display system. T cells bearing the newly isolated TCR bound pepMHC and were activated in the absence of co-receptor. This result demonstrates the feasibility of engineering full-length TCRs on the surface of T cells using a retroviral vector.
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