Characterization of Antigen Recognition by a T Lymphocyte Clone
Lee, Peter, Uang-Yin
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https://hdl.handle.net/2142/84802
Description
Title
Characterization of Antigen Recognition by a T Lymphocyte Clone
Author(s)
Lee, Peter, Uang-Yin
Issue Date
2002
Doctoral Committee Chair(s)
Kranz, David M.
Department of Study
Biochemistry
Discipline
Biochemistry
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Health Sciences, Immunology
Language
eng
Abstract
Chapter Four addresses the physiological T cell responses that can be elicited by peptide/MHC recognition. We demonstrated that the endogenously derived peptide, dEV8, functioned as both an agonist and an antagonist of T cells derived from 2C TCR transgenic mice. Although the exact mechanism underlying the opposing effects of the same pepMHC complex remains to be determined, differences in accessory molecules or coreceptors on the T cell surface may have a significant impact on T cell signaling and function.
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