Transcriptional Regulation of the Bacillus Subtilis pyrG Gene Encoding Cytidine Triphosphate Synthetase
Meng, Qi
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Permalink
https://hdl.handle.net/2142/84788
Description
Title
Transcriptional Regulation of the Bacillus Subtilis pyrG Gene Encoding Cytidine Triphosphate Synthetase
Author(s)
Meng, Qi
Issue Date
2002
Doctoral Committee Chair(s)
Switzer, Robert L.
Department of Study
Biochemistry
Discipline
Biochemistry
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Biology, Microbiology
Language
eng
Abstract
I propose that a trans-acting regulatory protein binds to the pyrG GGGC and GCUCCC sequences when intracellular CTP levels are low, which prevents the formation of the terminator and permits transcription readthrough. When intracellular CTP levels are high, I propose the regulatory protein dissociates from the pyrG leader RNA thereby allowing terminator formation and transcription termination.
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