University of Illinois Urbana-Champaign

Chemotactic Sensory Transduction in Bacillus Subtilis: A New Enzyme and a New Pathway

Kristich, Christopher James

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https://hdl.handle.net/2142/84787

Description

Title
Chemotactic Sensory Transduction in Bacillus Subtilis: A New Enzyme and a New Pathway
Author(s)
Kristich, Christopher James
Issue Date
2002
Doctoral Committee Chair(s)
Geroge W. Ordal
Department of Study
Biochemistry
Discipline
Biochemistry
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Biology, Microbiology
Language
eng
Abstract
Chemotaxis towards substrates of the phosphoenolpyruvate-dependent-phosphotransferase system (PTS) in E. coli is accomplished using a chemoreceptor-independent signaling circuit in which phosphoryl flux through the PTS is monitored and used directly to modulate the activity of the chemotactic kinase. In contrast, chemotaxis towards PTS carbohydrates by B. subtilis requires the transmembrane chemoreceptor McpC; therefore, B. subtilis must employ a different sensory circuit to mediate such chemotaxis. The results in this study indicate that the sensory circuit mediating chemotaxis towards PTS carbohydrates utilizes the cytoplasmic methyl-accepting subdomain of McpC as a sensor for PTS stimuli. This receptor subdomain has not been reported to function as a sensor of chemical stimuli for any known chemoreceptor.
Graduation Semester
2002
Type of Resource
text
Permalink
http://hdl.handle.net/2142/84787

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