Engineering and Characterization of High-Affinity T Cell Receptors
Holler, Phillip David
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Permalink
https://hdl.handle.net/2142/84786
Description
Title
Engineering and Characterization of High-Affinity T Cell Receptors
Author(s)
Holler, Phillip David
Issue Date
2002
Doctoral Committee Chair(s)
Kranz, David M.
Department of Study
Biochemistry
Discipline
Biochemistry
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Health Sciences, Immunology
Language
eng
Abstract
In Chapter 6, the role of TCR affinity in T cell activation was studied using CD8-negative T cells, as well as T cells expressing the co-receptor CD8. The peptide sensitivity of T cells that expressed the highest-affinity TCRs reached a plateau, suggesting the existence of an affinity maximum for T cell activation. Furthermore, CD8 requirements were directly related to the affinity of the TCR.
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