Lateral Membrane Domains Organize and Regulate Components of Signal Transduction Pathways
Wanaski, Stephen Philip
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https://hdl.handle.net/2142/84774
Description
Title
Lateral Membrane Domains Organize and Regulate Components of Signal Transduction Pathways
Author(s)
Wanaski, Stephen Philip
Issue Date
2001
Doctoral Committee Chair(s)
Glaser, Michael
Department of Study
Biochemistry
Discipline
Biochemistry
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Chemistry, Biochemistry
Language
eng
Abstract
Components of the mitogen activated protein kinase (MAPK) signaling cascade also localized into domains in vesicles containing acidic lipids. The formation of lateral membrane domains induced by Ki-Ras 4B and the Raf-cysteine rich domain (Raf-CRD) was inhibited by the anti-tumor agent farnesylthiosalicylic acid (FTS). The inhibition of Ras membrane domains by farnesylthiosalisylic acid was proposed to inhibit Ras function and the results provided a model of how the membrane organizes and regulates the MAP kinase signaling cascade.
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