The Development of Novel Non -Steroidal Subtype Selective Ligands for the Estrogen Receptor
Mortensen, Deborah Sue
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https://hdl.handle.net/2142/84490
Description
Title
The Development of Novel Non -Steroidal Subtype Selective Ligands for the Estrogen Receptor
Author(s)
Mortensen, Deborah Sue
Issue Date
2000
Doctoral Committee Chair(s)
Katzenellenbogen, John A.
Department of Study
Chemistry
Discipline
Chemistry
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Chemistry, Pharmaceutical
Language
eng
Abstract
A series of furan analogs were prepared bearing basic side-chains in the hope to impart anti-estrogenic activity to this class of ligands. The basic side-chain furan analogs were also ER-alpha binding selective ligands (2--47 fold selectivity) and transcriptional assays have shown one particular member of this series (Chapter 5, 17b) to be an ER-alpha selective antagonist (∼10 fold selectivity).
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