Production and Surface Modification of Protein Microspheres
Kufner, Gregory S.
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Permalink
https://hdl.handle.net/2142/84485
Description
Title
Production and Surface Modification of Protein Microspheres
Author(s)
Kufner, Gregory S.
Issue Date
2000
Doctoral Committee Chair(s)
Kenneth S. Suslick
Department of Study
Chemistry
Discipline
Chemistry
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Health Sciences, Pharmacology
Language
eng
Abstract
Previous work by Leamon and Lee has shown the successful targeting of folate labeled polyethylene glycol (PEGylated) liposomes to tumors that express folate receptors. Adaptation of this technology allowed approximately 6000 folate-PEG polymers per microsphere to be covalently linked to the surface of the albumin microspheres. A flow cytometry assay with KB cells, which express high levels of folate receptor, was unable to detect specific targeting of the microspheres under flow cytometry conditions.
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