Following Neuropeptide Processing, Distribution, Transport, and Release Using Novel Mass Spectrometric Approaches
Li, Lingjun
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Permalink
https://hdl.handle.net/2142/84471
Description
Title
Following Neuropeptide Processing, Distribution, Transport, and Release Using Novel Mass Spectrometric Approaches
Author(s)
Li, Lingjun
Issue Date
2000
Doctoral Committee Chair(s)
Sweedler, Jonathan V.
Department of Study
Chemistry
Discipline
Chemistry
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Chemistry, Biochemistry
Language
eng
Abstract
Using these strategies and the improved sampling protocols, a large number of novel peptides have been discovered in molluscan and other invertebrate model systems. The utility of MALDI-MS has grown from simple molecular-weight profiling to elegant experiments that enable the discovery and structural characterization of novel peptides. Such advancements, in combination with molecular biological, neurophysiological, and immunochemical approaches, should greatly expand our understanding of peptidergic communication in the central nervous system.
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