Functional and Mechanistic Investigations of Enzymes in the Enolase Superfamily
Hubbard, Brian Kent
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https://hdl.handle.net/2142/84465
Description
Title
Functional and Mechanistic Investigations of Enzymes in the Enolase Superfamily
Author(s)
Hubbard, Brian Kent
Issue Date
2000
Doctoral Committee Chair(s)
Gerlt, John A.
Department of Study
Chemistry
Discipline
Chemistry
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Chemistry, Organic
Language
eng
Abstract
In this thesis, the enolase superfamily is traced phylogentically and studied in detail to ascertain which active site residues are necessary to maintain function, kinetic competence, and/or substrate specificity. Methods for understanding the details of many enzymes in the enolase superfamily are developed as well as methods for predicting the function of previously uncharacterized members of the enolase superfamily.
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