Mass Spectrometric Characterization of Peptides in Neurons
Garden, Rebecca Wells
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https://hdl.handle.net/2142/84454
Description
Title
Mass Spectrometric Characterization of Peptides in Neurons
Author(s)
Garden, Rebecca Wells
Issue Date
1999
Doctoral Committee Chair(s)
Sweedler, Jonathan V.
Department of Study
Chemistry
Discipline
Chemistry
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Chemistry, Analytical
Language
eng
Abstract
The MALDI-based approach is inherently different from conventional methods, in that essentially all peptides present at significant concentrations are detected, not only those which are pre-selected or radioactively tagged. Furthermore, single cells, nerves, and vesicles are screened without the need to isolate each peptide from its complex cellular environment. Sampling, data acquisition, and strategies for the generation of molecular ion images are presented which reveal the utility of MALDI MS for direct and rapid neuropeptide characterization.
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