Chromatographic, Spectroscopic and Crystallographic Investigations of Chiral Recognition Processes
Koscho, Michael Edward
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https://hdl.handle.net/2142/84448
Description
Title
Chromatographic, Spectroscopic and Crystallographic Investigations of Chiral Recognition Processes
Author(s)
Koscho, Michael Edward
Issue Date
1999
Doctoral Committee Chair(s)
Pirkle, William H.
Department of Study
Chemistry
Discipline
Chemistry
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Chemistry, Analytical
Language
eng
Abstract
A number of experiments have been undertaken in order to determine, at the molecular level, the manner in which some of our recently developed low-molecular weight chiral selectors are capable of differentiating analyte enantiomers. When covalently linked to silica, these chiral selectors are capable of affording chromatographic enantioseparations. Series of homologous analytes were prepared and chromatographed on the chiral stationary phase of interest, in order to develop structure-selectivity relationships. Additionally, complexation with the chiral selector was investigated in solution (H NMR) and in the solid state (X-ray crystallography) utilizing soluble selector analogs and the analyte(s) of interest.
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