Synthesis and Evaluation of Aziridine Analogs of Presqualene Diphosphate as Squalene Synthase Inhibitors
Koohang, Ali
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https://hdl.handle.net/2142/84447
Description
Title
Synthesis and Evaluation of Aziridine Analogs of Presqualene Diphosphate as Squalene Synthase Inhibitors
Author(s)
Koohang, Ali
Issue Date
1999
Doctoral Committee Chair(s)
Coates, Robert M.
Department of Study
Chemistry
Discipline
Chemistry
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Chemistry, Organic
Language
eng
Abstract
The enhanced inhibitory activities of these novel aziridine diphosphate and methanediphosphonates towards squalene synthase compared to the analogous acyclic azabifarnesyl diphosphate may indicate a bridged non-classical, protonated cyclopropane intermediate in the formation of presqualene diphosphate.
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