Design, Syntheses and Functional Studies of DNA Binding Metal Complexes
Bauer, Cornelia
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https://hdl.handle.net/2142/84406
Description
Title
Design, Syntheses and Functional Studies of DNA Binding Metal Complexes
Author(s)
Bauer, Cornelia
Issue Date
1998
Doctoral Committee Chair(s)
Wang, Andrew H.J.
Department of Study
Chemistry
Discipline
Chemistry
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Chemistry, Pharmaceutical
Language
eng
Abstract
Both cis- and trans- (Pt(NH$\sb3)\sb2$(4-Me-Py)Cl$\rbrack\sp+$ bind DNA covalently at the N7-site of the guanines forming a monodentate adduct, but only the cis-isomer has anticancer activity. The interactions of these platinum complexes with the DNA-heptamer d(CCTGTCC):d(GGACAGG) were examined and a NMR based high resolution structure was determined. Surprisingly both platinum-DNA complexes do not form a very stable complex with its complementary strand. Over time the platinum-DNA complex decomposes and either the 2-methyl-pyridinium group or the platinum complex itself is detached. No interstrand crosslinking was observed.
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