Application of Chemiluminescent Detection to a Capillary Electrophoresis System Contained on a Glass Slide and the Development of Non-Flowing Electrogenerated Chemiluminescence Probes
Preston, J. Patrick
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https://hdl.handle.net/2142/84389
Description
Title
Application of Chemiluminescent Detection to a Capillary Electrophoresis System Contained on a Glass Slide and the Development of Non-Flowing Electrogenerated Chemiluminescence Probes
Author(s)
Preston, J. Patrick
Issue Date
1997
Doctoral Committee Chair(s)
Nieman, T.A.
Department of Study
Chemistry
Discipline
Chemistry
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Chemistry, Pharmaceutical
Language
eng
Abstract
A capillary electrophoresis system contained on a micromachined glass slide which integrates chemiluminescence as the detection method has been constructed and demonstrated as a feasible analytical technique. A simple method which does not require highly specialized facilities to manufacture these planar devices has concurrently been developed. This separation and detection system was characterized by separating and detecting mixtures of proline and tripropylamine. To further illustrate the applicability of this device, the anti-anxiety drug buspirone and its major metabolite 1-(2-pyrimidyl)piperazine were added to a human plasma matrix. The drug and metabolite were then separated from this matrix and detected.
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