Technetium-Labeled Receptor-Specific Radiopharmaceuticals: Synthesis of oxorhenium(V) Mimics of Steroid Hormones Based on the Integrated Approach
Hom, Roy Kay
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https://hdl.handle.net/2142/84365
Description
Title
Technetium-Labeled Receptor-Specific Radiopharmaceuticals: Synthesis of oxorhenium(V) Mimics of Steroid Hormones Based on the Integrated Approach
Author(s)
Hom, Roy Kay
Issue Date
1997
Doctoral Committee Chair(s)
Katzenellenbogen, John A.
Department of Study
Chemistry
Discipline
Chemistry
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Chemistry, Pharmaceutical
Language
eng
Abstract
Tetradentate oxorhenium(V) coordination motifs were subsequently investigated as possible modes by which the metal-chelate may be incorporated into a steroid-like structure. A novel amine amide thioether thiol (AATT) chelation paradigm was devised to replace the C and D rings of the steroid with a metal coordination sphere. A tetradentate oxorhenium(V) estradiol mimic was synthesized and exhibited much higher lipophilicity than the bis-bidentate DHT mimic, as well as sufficient stability to be assayed in vitro; however, it demonstrated low binding to the estrogen receptor.
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