The Total Synthesis and Cytoprotective Abilities of Dykellic Acid and Its Structural Analogs
Thompson, Christina
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https://hdl.handle.net/2142/84331
Description
Title
The Total Synthesis and Cytoprotective Abilities of Dykellic Acid and Its Structural Analogs
Author(s)
Thompson, Christina
Issue Date
2008
Doctoral Committee Chair(s)
Hergenrother, Paul J.
Department of Study
Chemistry
Discipline
Chemistry
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Chemistry, Pharmaceutical
Language
eng
Abstract
Experiments were also carried out to establish if dykellic acid's biological activity can be attributed to either of two well-established mechanisms, ROS quenching or caspase inhibition. Using fluorescent dyes sensitive to ROS it was established that dykellic acid is not capable of directly quenching ROS. Dykellic acid was also found to not directly inhibit caspase enzymes, an important family of enzymes in cellular death. While the mechanism of action of dykellic acid has yet to be elucidated, dykellic acid's potency and apparently nonstandard mechanism of action make it an interesting candidate for evaluation in models of cytoprotection.
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