Using Unnatural Amino Acids and Nonnative Cofactors for Metalloprotein Design and Engineering
Garner, Dewain K.
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https://hdl.handle.net/2142/84291
Description
Title
Using Unnatural Amino Acids and Nonnative Cofactors for Metalloprotein Design and Engineering
Author(s)
Garner, Dewain K.
Issue Date
2008
Doctoral Committee Chair(s)
Lu, Yi
Department of Study
Chemistry
Discipline
Chemistry
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Chemistry, Biochemistry
Language
eng
Abstract
Different positions for anchoring the salen cofactor to the Mb scaffold were observed to affect both the rate and selectivity of the artificial enzyme in a modular and accumulative fashion. Molecular dynamic simulations indicate that these changes may be due to the steric effects of the linker arms inside the protein cavity. The realization that the covalent anchors exert effects through interaction with substrates entering the pocket will help design better metalloproteins.
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