Exploring the Structural and Functional Characteristics of a Catalytic DNA
Kim, Hee-Kyung
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https://hdl.handle.net/2142/84286
Description
Title
Exploring the Structural and Functional Characteristics of a Catalytic DNA
Author(s)
Kim, Hee-Kyung
Issue Date
2007
Doctoral Committee Chair(s)
Lu, Yi
Department of Study
Chemistry
Discipline
Chemistry
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Chemistry, Biochemistry
Language
eng
Abstract
Finally, the use of DNAzymes in biosensing applications was studied for Pb2+ detection. The molecular beacon DNAzyme biosensor was shown to be capable of detecting Pb2+ in soft to moderately hard water sources when used in conjunction with a handheld fluorometer. Detection limits under these conditions were lower than 72 nM, which is the EPA standard for Pb2+ in drinking water. An electrochemical Pb2+ sensor has also been developed by conjugating a ferrocene moiety to a gold electrode immobilized DNAzyme system.
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