Investigation of Phospholipid Bilayer Interactions With Substrates, Polymers, and Nanoparticles
Spurlin, Tighe A.
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https://hdl.handle.net/2142/84281
Description
Title
Investigation of Phospholipid Bilayer Interactions With Substrates, Polymers, and Nanoparticles
Author(s)
Spurlin, Tighe A.
Issue Date
2007
Doctoral Committee Chair(s)
Gewirth, Andrew A.
Department of Study
Chemistry
Discipline
Chemistry
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Chemistry, Analytical
Language
eng
Abstract
The last experiments described investigate the ability of water dispersed fullerene aggregates to interact with and disrupt cell membranes. Bilayers composed of both neat zwitterionic lipid headgroups and cationic lipid headgroups were examined to investigate charge interactions between the lipid headgroups and negatively charged fullerene aggregates. Our results indicate that water soluble fullerenes adhere to lipid headgroups and may disrupt cellular functions by either radical generation or cell membrane passivition.
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