University of Illinois Urbana-Champaign

I. Synthetic Approaches Towards 2-Fluoroestradiol. II. Synthesis and Evaluation of Tacn-Rhenium Complexes as Estrogen Receptor Imaging Agents

Nickels, Michael

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https://hdl.handle.net/2142/84275

Description

Title
I. Synthetic Approaches Towards 2-Fluoroestradiol. II. Synthesis and Evaluation of Tacn-Rhenium Complexes as Estrogen Receptor Imaging Agents
Author(s)
Nickels, Michael
Issue Date
2007
Doctoral Committee Chair(s)
Katzenellenbogen, John A.
Department of Study
Chemistry
Discipline
Chemistry
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Chemistry, Organic
Language
eng
Abstract
While imaging ER levels in tumors can be done using F-18 labeled estrogens it is important to develop receptor imaging agents labeled with the widely available and less expensive technetium-99m radionuclide. We have explored the synthesis and evaluation of metal carbonyl complexes with 1,4,7-triazacyclononane. The results have suggested that these complexes are not suitable for ER imaging.
Graduation Semester
2007
Type of Resource
text
Permalink
http://hdl.handle.net/2142/84275

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