Immobilization of Catalytic DNA for Advanced Materials and Sensors
Wernette, Daryl Paul
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https://hdl.handle.net/2142/84267
Description
Title
Immobilization of Catalytic DNA for Advanced Materials and Sensors
Author(s)
Wernette, Daryl Paul
Issue Date
2007
Doctoral Committee Chair(s)
Lu, Yi
Department of Study
Chemistry
Discipline
Chemistry
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Chemistry, Analytical
Language
eng
Abstract
The DNAzyme was also immobilized on patterned glass surfaces via covalent attachment. Substrate-functionalized 100 nm polystyrene particles were then hybridized in the absence and presence of Pb2+. The result was the Pb2+-mediated tethering of particles onto patterned grids, where Pb2+ induced the cleavage of the DNAzyme complex and prevented assembly of the particles. The assembly of these advanced materials was monitored in real-time using laser diffraction and was characterized via scanning electron microscopy. Addition of 10 muM Pb2+ showed >99% inhibition of assembly.
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