Synthesis and Study of Biomimetic Ion Channels: (1) Toward the Development of a Cyclic Peptide-Based Redox-Gated Channel, and (2) Investigations Into the Effect of Pore Size on the Ion Selectivity of an Aminocyclodextrin Channel

Schmidt, Emily Grace

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Description

Title

Synthesis and Study of Biomimetic Ion Channels: (1) Toward the Development of a Cyclic Peptide-Based Redox-Gated Channel, and (2) Investigations Into the Effect of Pore Size on the Ion Selectivity of an Aminocyclodextrin Channel

Author(s)

Schmidt, Emily Grace

Issue Date

2007

Doctoral Committee Chair(s)

Mary S. Gin

Department of Study

Chemistry

Discipline

Chemistry

Degree Granting Institution

University of Illinois at Urbana-Champaign

Degree Name

Ph.D.

Degree Level

Dissertation

Keyword(s)

Chemistry, Organic

Language

eng

Abstract

To probe the correlation between pore size and ion selectivity, a channel with an alpha-cyclodextrin macrocycle was synthesized and its transport properties were compared with those of an analogous channel with a larger beta-cyclodextrin pore. The anion transport profile of the alpha-cyclodextrin channel (ClO 4- > I- > Br- > NO3- > Cl-) differed from that of its beta-cyclodextrin counterpart (ClO4 - > I- > NO3- > Br- > Cl-) in the order of bromide and nitrate transport rates. While quantitative comparisons could not be made between the rates of ion transport through the alpha- and beta-cyclodextrin channels, a number of qualitative differences were observed between the two sets of transport data. Namely, the smaller pore of the alpha-cyclodextrin channel appeared to bind Cl- in such a way as to restrict Na+ transport. In addition, the larger I- and ClO4- ions seemed to pass through channel-induced membrane defects rather than through the smaller pore of the alpha-cyclodextrin channel.

Graduation Semester

2007

Type of Resource

text

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