Imaging Prostate Cancer: Design, Synthesis, and in Vivo Testing of Steroidal and Non-Steroidal Androgen Selective PET Radiopharmaceuticals
Parent, Ephraim Edward
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https://hdl.handle.net/2142/84230
Description
Title
Imaging Prostate Cancer: Design, Synthesis, and in Vivo Testing of Steroidal and Non-Steroidal Androgen Selective PET Radiopharmaceuticals
Author(s)
Parent, Ephraim Edward
Issue Date
2006
Doctoral Committee Chair(s)
Katzenellenbogen, John A.
Department of Study
Chemistry
Discipline
Chemistry
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Health Sciences, Radiology
Language
eng
Abstract
In addition to our non-steroidal work, we have designed and synthesized some high affinity steroidal compounds to probe the mechanism of androgen delivery to the cellular AR transcription mechanism. Sex hormone binding globulin (SHBG) binds testosterone, the principal circulating androgen, in high affinity and is believed to be directly involved in delivery of the hormone to cytoplasmic AR. Other high-affinity AR compounds, such as nor-testosterone, do not bind SHBG and their potential as imaging agents is not clear. We have prepared two classes of high affinity AR, 18F-labeled steroidal compounds, one of which also binds with high affinity to SHBG. In addition, we have studied their distribution in rat models in hope to elucidate the role that SHBG plays in radiopharmaceutical delivery.
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