Design and Synthesis of Small Molecule Regulators of Steroid Receptor Action
Trogden, Bridget G.
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Permalink
https://hdl.handle.net/2142/84203
Description
Title
Design and Synthesis of Small Molecule Regulators of Steroid Receptor Action
Author(s)
Trogden, Bridget G.
Issue Date
2005
Doctoral Committee Chair(s)
Katzenellenbogen, John A.
Department of Study
Chemistry
Discipline
Chemistry
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Chemistry, Organic
Language
eng
Abstract
Another way of blocking estrogen-related actions is to prevent transcription via the creation of coactivator binding inhibitors. The estrogen receptor contains a region in the ligand binding domain where coactivator proteins for transcription are able to dock. Using a small molecule specifically designed to bind to this region with a high affinity effectively inhibits transcription. Molecules were designed and synthesized to mimic the interactions between the coactivator protein and the estrogen receptor.
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