From Small Molecules to Neurotoxins: Characterizing Neuromodulatory Compounds Using Liquid Chromatography Coupled to Mass Spectrometry
Jakubowski, Jennifer A.
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Permalink
https://hdl.handle.net/2142/84174
Description
Title
From Small Molecules to Neurotoxins: Characterizing Neuromodulatory Compounds Using Liquid Chromatography Coupled to Mass Spectrometry
Author(s)
Jakubowski, Jennifer A.
Issue Date
2005
Doctoral Committee Chair(s)
Sweedler, Jonathan V.
Department of Study
Chemistry
Discipline
Chemistry
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Biology, Neuroscience
Language
eng
Abstract
Thus, this work demonstrates mass spectrometric approaches for analyzing biological samples from a variety of animal models resulting in detailed chemical and structural characterization of highly modified toxins, neuropeptides, and small molecules, which can ultimately contribute to our understanding of how chemical transmission, signaling and modulation within the central nervous system are related to behavior, learning and memory.
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