Novel Approaches for the Measurement of Unusual Post-Translational Modifications in Neuropeptides
Sheeley, Sarah Abigail
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https://hdl.handle.net/2142/84171
Description
Title
Novel Approaches for the Measurement of Unusual Post-Translational Modifications in Neuropeptides
Author(s)
Sheeley, Sarah Abigail
Issue Date
2004
Doctoral Committee Chair(s)
Sweedler, Jonathan V.
Department of Study
Chemistry
Discipline
Chemistry
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Chemistry, Analytical
Language
eng
Abstract
Other PTMs, such as the transformation of L-amino acid residues to the D-configuration, do not result in a measurable mass change. Capillary electrophoresis combined with mass spectrometry is used to identify cells containing a D-amino acid-containing peptide found in Aplysia. These cells are then utilized in the development of a method combining the specificity of an enzyme with liquid chromatography/mass spectrometry to locate novel D-amino acid-containing peptides in the central nervous system of Aplysia californica.
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