Mechanism of the Neural Cell Adhesion Molecule and Mode of Polysialic Acid Adhesive Inhibition
Johnson, Colin
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Permalink
https://hdl.handle.net/2142/84167
Description
Title
Mechanism of the Neural Cell Adhesion Molecule and Mode of Polysialic Acid Adhesive Inhibition
Author(s)
Johnson, Colin
Issue Date
2004
Doctoral Committee Chair(s)
Leckband, Deborah E.
Department of Study
Chemistry
Discipline
Chemistry
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Biology, Cell
Language
eng
Abstract
Lastly, direct force measurements are presented on polysialylated NCAM proteins to determine the effects of polysialic acid on both NCAM and C-cadherin mediated adhesion. Results indicate that polysialic acid inhibits both NCAM and cadherin adhesion by increasing the intermembrane repulsion. This inhibitory effect was dependant on both polysialic acid surface density and on ionic strength.
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