University of Illinois Urbana-Champaign

Investigating the Tyrosine-Histidine Linkage in the Copper B Site of Cytochrome C Oxidase: Model Studies Utilizing a Zinc Imidazole-Phenol Containing Complex

Pesavento, Russell P.

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Description

Title
Investigating the Tyrosine-Histidine Linkage in the Copper B Site of Cytochrome C Oxidase: Model Studies Utilizing a Zinc Imidazole-Phenol Containing Complex
Author(s)
Pesavento, Russell P.
Issue Date
2004
Doctoral Committee Chair(s)
van der Donk, Wilfred A.
Department of Study
Chemistry
Discipline
Chemistry
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Chemistry, Inorganic
Language
eng
Abstract
A chelating ligand (BPAIP) was synthesized incorporating an ortho substituted imidazole-phenol moiety. The resultant Zn(II) complex, [Zn(BPAIP)(Br)]+, was found to exhibit a decreased pK A (8.24) and increased oxidation potential relative to the unbound BPAIP. In addition, the stability of [Zn(BPAIP)(Br)]+ in buffered D2O was found to be pH dependent. The increased stability of [Zn(BPAIP)(Br)] + in buffered D2O at basic pH coincides with the experimentally determined pKA of the phenolic proton of BPAIP. This implies changes in the donating ability of the imidazole to Zn(II) as a result of the protonation state of the cross-linked phenol. Thus, the linkage could serve to make the imidazole a stronger ligand to Zn(II).
Graduation Semester
2004
Type of Resource
text
Permalink
http://hdl.handle.net/2142/84161

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