Top Down Mass Spectrometry of Archaea and Human Tumor Cells
Forbes, Andrew James
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https://hdl.handle.net/2142/84151
Description
Title
Top Down Mass Spectrometry of Archaea and Human Tumor Cells
Author(s)
Forbes, Andrew James
Issue Date
2004
Doctoral Committee Chair(s)
Kelleher, Neil L.
Department of Study
Chemistry
Discipline
Chemistry
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Chemistry, Analytical
Language
eng
Abstract
A final study was performed applying the top down platform to human HeLa tumor cells. Thirty-four proteins in all were identified, and >90% of these were fully characterized. Several proteins harbored post-translational modifications including N-terminal and internal acetylations, methylations, disulfide bonds, and protein truncations. Proteins were also characterized with known coding single nucleotide polymorphisms, alternative splice variants, and highly homologous gene family members.
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