Fluorescent-Labeled Estrogen Receptors: Molecular Sensors of Receptor Structure and Function
Tamrazi, Anobel
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Permalink
https://hdl.handle.net/2142/84109
Description
Title
Fluorescent-Labeled Estrogen Receptors: Molecular Sensors of Receptor Structure and Function
Author(s)
Tamrazi, Anobel
Issue Date
2003
Doctoral Committee Chair(s)
Katzenellenbogen, John A.
Department of Study
Chemistry
Discipline
Chemistry
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Biophysics, Medical
Language
eng
Abstract
By attaching the fluorophore directly onto the ligand-binding domain, we have created out of the ER a molecular sensor through which we can probe directly the conformational state of the receptor with high sensitivity. Thus, fluorophore-labeled ERs provide tools for studying receptor structure and function that nicely complement x-ray crystallography and NMR spectroscopy.
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