University of Illinois Urbana-Champaign

Electronic Relaxation Properties of Gadolinium Based MRI Contrast Agents

Kang, Hoon

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https://hdl.handle.net/2142/84081

Description

Title
Electronic Relaxation Properties of Gadolinium Based MRI Contrast Agents
Author(s)
Kang, Hoon
Issue Date
2002
Doctoral Committee Chair(s)
  • Belford, R. Linn
  • Clarkson, Robert B.
Department of Study
Chemistry
Discipline
Chemistry
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Health Sciences, Radiology
Language
eng
Abstract
In order to increase our understanding of the relationship between the gadolinium chelate's chemical structure and its effectiveness as a MRI contrast agent, we have prepared and studied a number of chelates with ranging characteristics. We have found that the metal-ligand binding of chelates is important in determining the ZFS and tauv. We also investigated the role of the cage rigidity of the chelate, and studied its effect on tauv. Finally, we hope that our study can stimulate synthesis 'Smart Contrast Agents' that utilizes the changes in electron relaxation rate upon changes in structure.
Graduation Semester
2002
Type of Resource
text
Permalink
http://hdl.handle.net/2142/84081

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