Part I: The Large-Scale Synthesis of Hyaluronan Disaccharides Utilizing a Mild Cleavage of 2-Amino-2-Deoxy-D-Glucoside Methoxycarbonyl Derivatives With Methyltrichlorosilane and the Application for the Synthesis of Carbohydrate Polymers. Part II: The Synthesis of Models for Use in Studying the Solution Behavior of Carbohydrates in a Hydrophobic Environment

Werner, Sara Lynn Adamski

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Description

Title

Part I: The Large-Scale Synthesis of Hyaluronan Disaccharides Utilizing a Mild Cleavage of 2-Amino-2-Deoxy-D-Glucoside Methoxycarbonyl Derivatives With Methyltrichlorosilane and the Application for the Synthesis of Carbohydrate Polymers. Part II: The Synthesis of Models for Use in Studying the Solution Behavior of Carbohydrates in a Hydrophobic Environment

Author(s)

Werner, Sara Lynn Adamski

Issue Date

2001

Doctoral Committee Chair(s)

Petillo, Peter A.

Department of Study

Chemistry

Discipline

Chemistry

Degree Granting Institution

University of Illinois at Urbana-Champaign

Degree Name

Ph.D.

Degree Level

Dissertation

Keyword(s)

Chemistry, Organic

Language

eng

Abstract

A better understanding of the solution behavior of carbohydrates, specifically the investigation into their hydrophobicity, would allow for a better understanding of the carbohydrate interactions occurring at a cellular level. The syntheses of model compounds incorporating a hydrophobic pyrene scaffold symmetrically tethered to carbohydrate moieties were completed. The carbohydrate moieties integrated a beta-D-glucose functional group coupled to a p-nitrophenyl carbamate with varying alkyl chain lengths and were tethered to a pyrene core through a urea linkage installed to provide water solubility.

Graduation Semester

2001

Type of Resource

text

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http://hdl.handle.net/2142/84059

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