Micromachined Sensors and Their Applications in the Study of Mechanical Response of Single Living Cells
Yang, Shengyuan
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https://hdl.handle.net/2142/83893
Description
Title
Micromachined Sensors and Their Applications in the Study of Mechanical Response of Single Living Cells
Author(s)
Yang, Shengyuan
Issue Date
2007
Doctoral Committee Chair(s)
Saif, M. Taher A.
Department of Study
Mechanical Engineering
Discipline
Mechanical Engineering
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Biophysics, General
Language
eng
Abstract
Both the one- and two-component force sensors have been used to study the mechanobiological response of fibroblasts, endothelial cells, and neurons. The major findings of the studies include: The force response of monkey kidney fibroblasts is strongly linear, reversible and repeatable under large deformations, with a small stiffening at the initial deformation stage; Actin filaments play a dominant role in taking the cellular internal forces; Mechanical indentation/compression may induce actin agglomeration inside the cell, which supplies a perfect example of cellular mechanotransduction; The in vivo stretch force response of Drosophila axons is linear, and there is a rest tension in the axons and they maintain this rest tension; Tension in the axons is required for normal synaptic function, and muscle twitches may be involved in tuning this tension.
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