Regulation of Phospholipid Transfer Protein Secretion and Gene Expression in the Hepatoma Cell Line, HepG2
Guo, Ziwen
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Permalink
https://hdl.handle.net/2142/83722
Description
Title
Regulation of Phospholipid Transfer Protein Secretion and Gene Expression in the Hepatoma Cell Line, HepG2
Author(s)
Guo, Ziwen
Issue Date
1997
Doctoral Committee Chair(s)
Nishida, Toshiro
Department of Study
Food Science and Human Nutrition
Discipline
Food Science and Human Nutrition
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Chemistry, Biochemistry
Language
eng
Abstract
Hep G2 cells were used as a model to study HDL distribution and interconversion corresponding to variations in PLTP activity. An increase in PLTP activity by butyrate treatment was accompanied by increases in the amount of HDL having a hydrated density of 1.10 g/ml, HDL particle size and the amounts of both pre-$\beta$ HDL and $\alpha$-HDL. In contrast, inhibition of PLTP activity in the cell medium by anti-PLTP IgG resulted in a decrease in the secreted HDL fraction having a hydrated density of 1.10 g/ml. This reduction was also associated with decreases in the amounts of pre-$\beta$ HDL and $\alpha$-HDL.
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