Metabolic and Intestinal Immune Responses During Neonatal and Weaning Periods in Pigs
McCracken, Barbara Anne
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https://hdl.handle.net/2142/83643
Description
Title
Metabolic and Intestinal Immune Responses During Neonatal and Weaning Periods in Pigs
Author(s)
McCracken, Barbara Anne
Issue Date
1998
Doctoral Committee Chair(s)
Gaskins, H. Rex
Department of Study
Animal Sciences
Discipline
Animal Sciences
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Biology, Animal Physiology
Language
eng
Abstract
Together these experiments address metabolic and intestinal responses to diet in pigs during the weaning and neonatal periods. Significant findings include the observation that soy-based diets do not result in intestinal inflammation in neonatal pigs supporting the use of soy proteins as alternatives to milk protein in infant formulas. Evidence that reduced feed intake post-weaning causes local inflammatory responses that may lead to villus atrophy is presented. Further, results presented demonstrate a possible relationship between enzymes responsible for normal extracellular matrix turnover and increased T-cell numbers in the intestine suggesting that T-cell-mediated inflammation may induce expression of these enzymes resulting in weaning- associated structural changes in the intestine.
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