Defining Mechanisms Contributing to Porcine MHC Class II Diversity
Luetkemeier, Erin Suzanne
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https://hdl.handle.net/2142/83618
Description
Title
Defining Mechanisms Contributing to Porcine MHC Class II Diversity
Author(s)
Luetkemeier, Erin Suzanne
Issue Date
2008
Doctoral Committee Chair(s)
Schook, Lawrence B.
Department of Study
Animal Sciences
Discipline
Animal Sciences
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Biology, Genetics
Language
eng
Abstract
Comparisons of He in domestic and Wild populations revealed significant differences within Europe (P=0.031) at the DRB1 loci, but not the DQB loci (P=0.503). Within Asia, significant differences were observed (DQB: P=0.011 and DRB1: P=0.015) at both MHC loci, between the domestic and Wild boar populations. The European and Asian domestic populations exhibited a higher level of DQB amino acid diversity (0.093 and 0.093, respectively) when compared to the respective Wild boar populations (0.047 and 0.055). Conversely, analyses of DRB1 amino acid diversity revealed lower levels for both European and Asian domestic populations (0.125 and 0.121, respectively) when compared to European and Asian Wild boar populations (0.170 and 0.152, respectively). Lower DQB diversity in the Wild boar populations when compared to the domestic populations may suggest relaxed selection in the domestic populations at the DQB locus. Taken together, these data suggest that MHC polymorphisms have been selectively maintained, possibly by balancing selection, having overcome the effects of nonselective factors, artificial selection, distinct ancestral origins therefore lacking the presence of geographic signatures.
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