Multi-Scale Osteointegration and Neovascularization of Biphasic Calcium Phosphate Bone Scaffolds
Lan, Sheeny K.
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https://hdl.handle.net/2142/82858
Description
Title
Multi-Scale Osteointegration and Neovascularization of Biphasic Calcium Phosphate Bone Scaffolds
Author(s)
Lan, Sheeny K.
Issue Date
2009
Doctoral Committee Chair(s)
Johnson, Amy J. Wagoner
Jamison, Russell D.
Department of Study
Materials Science and Engineering
Discipline
Materials Science and Engineering
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Engineering, Materials Science
Language
eng
Abstract
Collectively, the thesis demonstrates that (1) the design of synthetic bone scaffolds should include controlled multi-scale porosity to promote multi-scale osteointegration, which may significantly improve scaffold mechanical properties and (2) human umbilical cord blood-derived endothelial colony forming cells have potential for promoting neovascularization in a bone defect when combined with rhBMP-2.
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